Drug interactions
Bupropion + Glipizide-metformin
Severity: Minor
Bupropion and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may raise metformin concentrations by inhibiting renal transporters, which could increase glucose-lowering effect and adverse effects. The clinical significance appears modest.
What this interaction means in plain words
Bupropion and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Glipizide-metformin belongs to Endocrine.
Why it happens
Inhibition of OCT2-mediated renal tubular secretion of metformin.
What to do
Monitor blood glucose and metformin tolerability, and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Glipizide-metformin?
MediHelp rates the interaction as minor. Bupropion and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion may raise metformin concentrations by inhibiting renal transporters, which could increase glucose-lowering effect and adverse effects. The clinical significance appears modest.
How serious is the interaction between Bupropion and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and metformin tolerability, and adjust the dose if needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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