Drug interactions
Bupropion + Glyburide-metformin
Severity: Minor
Bupropion and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may inhibit OCT2-mediated renal secretion of metformin, raising metformin concentrations. Higher exposure may increase adverse effects, although the change is usually modest.
What this interaction means in plain words
Bupropion and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
Why it happens
Inhibition of the organic cation transporter OCT2 reduces renal tubular secretion of metformin.
What to do
Monitor glycemic control and renal function. Reduce the metformin dose if gastrointestinal intolerance occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Glyburide-metformin?
MediHelp rates the interaction as minor. Bupropion and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion may inhibit OCT2-mediated renal secretion of metformin, raising metformin concentrations. Higher exposure may increase adverse effects, although the change is usually modest.
How serious is the interaction between Bupropion and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function. Reduce the metformin dose if gastrointestinal intolerance occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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