Drug interactions
Bupropion + Metformin-repaglinide
Severity: Minor
Bupropion and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion and its metabolites may inhibit renal tubular secretion of metformin, which could raise metformin concentrations. Bupropion is also a CYP2B6 substrate and not a clear modifier of repaglinide. The clinical effect is generally modest.
What this interaction means in plain words
Bupropion and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
Possible inhibition of OCT2-mediated renal secretion of metformin.
What to do
Monitor glucose control and watch for metformin adverse effects, especially in patients with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Metformin-repaglinide?
MediHelp rates the interaction as minor. Bupropion and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion and its metabolites may inhibit renal tubular secretion of metformin, which could raise metformin concentrations. Bupropion is also a CYP2B6 substrate and not a clear modifier of repaglinide. The clinical effect is generally modest.
How serious is the interaction between Bupropion and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control and watch for metformin adverse effects, especially in patients with reduced renal function.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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