Drug interactions
Bupropion + Nelfinavir
Severity: Moderate
Bupropion and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir may alter bupropion metabolism, raising parent drug levels while lowering hydroxybupropion concentrations. The clinical effect on efficacy or toxicity is uncertain.
What this interaction means in plain words
Bupropion and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Nelfinavir belongs to Anti Virals.
Why it happens
Altered CYP2B6-mediated bupropion metabolism by nelfinavir; net effect is not fully characterized.
What to do
Monitor clinical response and for adverse effects including insomnia, tremor and seizures. Adjust bupropion dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Bupropion with Nelfinavir?
MediHelp rates the interaction as moderate. Bupropion and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir may alter bupropion metabolism, raising parent drug levels while lowering hydroxybupropion concentrations. The clinical effect on efficacy or toxicity is uncertain.
How serious is the interaction between Bupropion and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and for adverse effects including insomnia, tremor and seizures. Adjust bupropion dose to response.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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