Drug interactions
Bupropion + Sorafenib
Severity: Minor
Bupropion and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib has been reported to inhibit CYP2B6 in vitro, which could raise bupropion levels and reduce hydroxybupropion formation. The clinical relevance has not been established.
What this interaction means in plain words
Bupropion and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Possible CYP2B6 inhibition by sorafenib; clinical mechanism not firmly established.
What to do
Monitor for bupropion adverse effects such as insomnia, agitation and seizures, and reduce the bupropion dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Bupropion with Sorafenib?
MediHelp rates the interaction as minor. Bupropion and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sorafenib has been reported to inhibit CYP2B6 in vitro, which could raise bupropion levels and reduce hydroxybupropion formation. The clinical relevance has not been established.
How serious is the interaction between Bupropion and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bupropion adverse effects such as insomnia, agitation and seizures, and reduce the bupropion dose if they occur.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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