Drug interactions
Bupropion + Timolol
Severity: Moderate
Bupropion and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol is metabolized mainly by CYP2D6, so bupropion can increase systemic timolol levels. This may cause more bradycardia, hypotension or bronchospasm, including with ophthalmic timolol in susceptible patients.
What this interaction means in plain words
Bupropion and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Bupropion inhibits CYP2D6, decreasing the hepatic clearance of timolol.
What to do
Monitor heart rate and blood pressure, and respiratory status in patients with asthma or COPD. Reduce the timolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Bupropion with Timolol?
MediHelp rates the interaction as moderate. Bupropion and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Timolol is metabolized mainly by CYP2D6, so bupropion can increase systemic timolol levels. This may cause more bradycardia, hypotension or bronchospasm, including with ophthalmic timolol in susceptible patients.
How serious is the interaction between Bupropion and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and respiratory status in patients with asthma or COPD. Reduce the timolol dose if bradycardia or hypotension develops.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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