Drug interactions
Bupropion + Tolterodine
Severity: Moderate
Bupropion and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion can increase exposure to tolterodine by inhibiting its main CYP2D6 metabolic route. Anticholinergic effects such as dry mouth, constipation, urinary retention and QT effects may become more prominent.
What this interaction means in plain words
Bupropion and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Bupropion inhibits CYP2D6, reducing conversion of tolterodine to its 5-hydroxymethyl metabolite.
What to do
Monitor for anticholinergic adverse effects and consider limiting tolterodine to a lower dose, such as 1 mg twice daily. Take extra care in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Tolterodine
Frequently asked questions
Can I take Bupropion with Tolterodine?
MediHelp rates the interaction as moderate. Bupropion and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion can increase exposure to tolterodine by inhibiting its main CYP2D6 metabolic route. Anticholinergic effects such as dry mouth, constipation, urinary retention and QT effects may become more prominent.
How serious is the interaction between Bupropion and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and consider limiting tolterodine to a lower dose, such as 1 mg twice daily. Take extra care in patients with QT risk factors.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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