Drug interactions
Bupropion + Zuranolone
Severity: Moderate
Bupropion and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes CNS depression, including somnolence and impaired driving ability, and other CNS-active drugs may add to this. Bupropion is typically stimulating, so the clinical interaction is likely limited. Bupropion can also lower seizure threshold, which may be relevant in patients with a seizure history.
What this interaction means in plain words
Bupropion and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Pharmacodynamic CNS effects of zuranolone, a GABA-A positive modulator, may be altered or added to by other CNS-active drugs.
What to do
Counsel patients not to drive for at least 12 hours after each zuranolone dose, and reduce the zuranolone dose if excess sedation occurs. Monitor for sedation and seizure activity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Bupropion with Zuranolone?
MediHelp rates the interaction as moderate. Bupropion and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes CNS depression, including somnolence and impaired driving ability, and other CNS-active drugs may add to this. Bupropion is typically stimulating, so the clinical interaction is likely limited. Bupropion can also lower seizure threshold, which may be relevant in patients with a seizure history.
How serious is the interaction between Bupropion and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive for at least 12 hours after each zuranolone dose, and reduce the zuranolone dose if excess sedation occurs. Monitor for sedation and seizure activity.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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