Drug interactions
Bupropion-naltrexone + Clozapine
Severity: Major
Bupropion-naltrexone and Clozapine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower the seizure threshold, and clozapine already carries a dose-related seizure risk. Bupropion may also raise clozapine exposure through CYP2D6 inhibition.
What this interaction means in plain words
Bupropion-naltrexone and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion-naltrexone belongs to Miscellaneous; Clozapine belongs to Central Nervous System.
Why it happens
Additive lowering of seizure threshold, with a possible CYP2D6-mediated increase in clozapine levels.
What to do
Avoid if feasible; if used together, keep doses low, titrate slowly and monitor for seizures and clozapine adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Bupropion-naltrexone with Clozapine?
MediHelp rates the interaction as major. Bupropion-naltrexone and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs lower the seizure threshold, and clozapine already carries a dose-related seizure risk. Bupropion may also raise clozapine exposure through CYP2D6 inhibition.
How serious is the interaction between Bupropion-naltrexone and Clozapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if feasible; if used together, keep doses low, titrate slowly and monitor for seizures and clozapine adverse effects.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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