Drug interactions
Bupropion-naltrexone + Cyclobenzaprine
Severity: Moderate
Bupropion-naltrexone and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and has serotonergic and seizure-lowering properties. Combined with bupropion, there is a possible increase in seizure risk and a small risk of serotonin toxicity.
What this interaction means in plain words
Bupropion-naltrexone and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Cyclobenzaprine belongs to Musculoskeletal.
Why it happens
Additive seizure-threshold lowering and weak serotonergic effects; bupropion CYP2D6 inhibition may also raise cyclobenzaprine exposure.
What to do
Use the lowest effective doses and limit duration of cyclobenzaprine. Monitor for agitation, tremor, hyperreflexia and seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is structurally related to tricyclic antidepressants and has serotonergic and seizure-lowering properties. Combined with bupropion, there is a possible increase in seizure risk and a small risk of serotonin toxicity.
How serious is the interaction between Bupropion-naltrexone and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and limit duration of cyclobenzaprine. Monitor for agitation, tremor, hyperreflexia and seizures.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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