Drug interactions
Bupropion-naltrexone + Efavirenz
Severity: Moderate
Bupropion-naltrexone and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz induces the metabolism of bupropion, lowering concentrations of the parent drug and potentially reducing its efficacy. Exposure to hydroxybupropion may be altered, so the overall effect is unpredictable.
What this interaction means in plain words
Bupropion-naltrexone and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induces hepatic enzymes (including CYP2B6) that metabolize bupropion.
What to do
Monitor clinical response to bupropion-naltrexone and consider a dose increase within labeled limits if effect is lost. Do not exceed the maximum recommended dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Efavirenz?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz induces the metabolism of bupropion, lowering concentrations of the parent drug and potentially reducing its efficacy. Exposure to hydroxybupropion may be altered, so the overall effect is unpredictable.
How serious is the interaction between Bupropion-naltrexone and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to bupropion-naltrexone and consider a dose increase within labeled limits if effect is lost. Do not exceed the maximum recommended dose.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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