Drug interactions
Bupropion-naltrexone + Galantamine
Severity: Moderate
Bupropion-naltrexone and Galantamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Galantamine is partly cleared by CYP2D6, so bupropion can increase its concentrations. This may increase cholinergic effects such as nausea, vomiting, bradycardia and dizziness.
What this interaction means in plain words
Bupropion-naltrexone and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Galantamine belongs to Central Nervous System.
Why it happens
Bupropion inhibits CYP2D6, decreasing galantamine metabolism.
What to do
Monitor for nausea, bradycardia and other cholinergic effects, and lower the galantamine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Bupropion-naltrexone with Galantamine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Galantamine is partly cleared by CYP2D6, so bupropion can increase its concentrations. This may increase cholinergic effects such as nausea, vomiting, bradycardia and dizziness.
How serious is the interaction between Bupropion-naltrexone and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea, bradycardia and other cholinergic effects, and lower the galantamine dose if they occur.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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