Drug interactions
Bupropion-naltrexone + Imipramine
Severity: Major
Bupropion-naltrexone and Imipramine: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6, raising imipramine and desipramine levels, with greater anticholinergic, cardiac and sedative effects. Both drugs also lower seizure threshold, so seizure risk is increased.
What this interaction means in plain words
Bupropion-naltrexone and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion-naltrexone belongs to Miscellaneous; Imipramine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by bupropion plus additive seizure threshold lowering.
What to do
Use lower imipramine doses and monitor tricyclic levels, ECG and signs of toxicity. Keep the bupropion dose as low as possible and avoid in patients with seizure risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Imipramine?
MediHelp rates the interaction as major. Bupropion-naltrexone and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bupropion inhibits CYP2D6, raising imipramine and desipramine levels, with greater anticholinergic, cardiac and sedative effects. Both drugs also lower seizure threshold, so seizure risk is increased.
How serious is the interaction between Bupropion-naltrexone and Imipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower imipramine doses and monitor tricyclic levels, ECG and signs of toxicity. Keep the bupropion dose as low as possible and avoid in patients with seizure risk.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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