Drug interactions
Bupropion-naltrexone + Lofexidine
Severity: Moderate
Bupropion-naltrexone and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6 and may increase lofexidine exposure, raising the risk of hypotension, orthostasis, bradycardia and sedation. Lofexidine may also change naltrexone exposure, though the clinical significance is unclear.
What this interaction means in plain words
Bupropion-naltrexone and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Lofexidine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by bupropion reduces lofexidine clearance, with additive hypotensive and bradycardic effects.
What to do
Monitor blood pressure and heart rate, and consider reducing the lofexidine dose. Counsel patients about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Bupropion-naltrexone with Lofexidine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion inhibits CYP2D6 and may increase lofexidine exposure, raising the risk of hypotension, orthostasis, bradycardia and sedation. Lofexidine may also change naltrexone exposure, though the clinical significance is unclear.
How serious is the interaction between Bupropion-naltrexone and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and consider reducing the lofexidine dose. Counsel patients about orthostatic symptoms.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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