Drug interactions
Buspirone + Desipramine
Severity: Minor
Buspirone and Desipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine mainly inhibits noradrenaline reuptake with weaker serotonergic action, so the serotonin syndrome risk with buspirone is low. Awareness is still advised.
What this interaction means in plain words
Buspirone and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buspirone belongs to Central Nervous System; Desipramine belongs to Central Nervous System.
Why it happens
Possible modest additive serotonergic effect with buspirone 5-HT1A agonism.
What to do
No routine change is needed; counsel the patient to report agitation, tremor or fever.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Buspirone with Desipramine?
MediHelp rates the interaction as minor. Buspirone and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desipramine mainly inhibits noradrenaline reuptake with weaker serotonergic action, so the serotonin syndrome risk with buspirone is low. Awareness is still advised.
How serious is the interaction between Buspirone and Desipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel the patient to report agitation, tremor or fever.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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