Drug interactions
Buspirone + Duvelisib
Severity: Moderate
Buspirone and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates such as buspirone. Higher buspirone levels may cause dizziness, drowsiness and nausea.
What this interaction means in plain words
Buspirone and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Duvelisib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated buspirone metabolism by duvelisib.
What to do
Consider a lower buspirone starting dose and monitor for adverse effects such as sedation and dizziness. Adjust the dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Buspirone with Duvelisib?
MediHelp rates the interaction as moderate. Buspirone and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates such as buspirone. Higher buspirone levels may cause dizziness, drowsiness and nausea.
How serious is the interaction between Buspirone and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower buspirone starting dose and monitor for adverse effects such as sedation and dizziness. Adjust the dose according to response.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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