Drug interactions
Buspirone + Gabapentin enacarbil
Severity: Moderate
Buspirone and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, and combined use may increase sedation and psychomotor impairment. Gabapentinoids add to CNS depression and can contribute to respiratory depression in susceptible patients.
What this interaction means in plain words
Buspirone and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depressant effects.
What to do
Start with the lowest effective doses and warn the patient about impaired driving and alertness. Monitor sedation and respiratory status, especially in older patients or those with respiratory disease or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Buspirone with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Buspirone and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness, and combined use may increase sedation and psychomotor impairment. Gabapentinoids add to CNS depression and can contribute to respiratory depression in susceptible patients.
How serious is the interaction between Buspirone and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and warn the patient about impaired driving and alertness. Monitor sedation and respiratory status, especially in older patients or those with respiratory disease or renal impairment.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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