Drug interactions
Buspirone + Lapatinib
Severity: Moderate
Buspirone and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and may raise buspirone plasma concentrations, which are highly sensitive to CYP3A4 inhibition. Increased dizziness, sedation, nausea or headache may occur.
What this interaction means in plain words
Buspirone and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by lapatinib reduces first-pass and systemic metabolism of buspirone.
What to do
Begin buspirone at a low dose and titrate cautiously, monitoring for sedation and dizziness. Reduce the buspirone dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Buspirone with Lapatinib?
MediHelp rates the interaction as moderate. Buspirone and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and may raise buspirone plasma concentrations, which are highly sensitive to CYP3A4 inhibition. Increased dizziness, sedation, nausea or headache may occur.
How serious is the interaction between Buspirone and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin buspirone at a low dose and titrate cautiously, monitoring for sedation and dizziness. Reduce the buspirone dose if adverse effects develop.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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