Drug interactions
Buspirone + Maprotiline
Severity: Moderate
Buspirone and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buspirone and maprotiline both act on serotonergic and noradrenergic pathways, so serotonin toxicity is possible, although maprotiline is mainly a noradrenaline reuptake inhibitor. Maprotiline also lowers seizure threshold, which adds to the need for caution.
What this interaction means in plain words
Buspirone and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on monoaminergic neurotransmission, with buspirone 5-HT1A agonism combined with maprotiline reuptake inhibition.
What to do
Use the lowest effective doses and increase gradually. Monitor for signs of serotonin syndrome, particularly after dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Buspirone with Maprotiline?
MediHelp rates the interaction as moderate. Buspirone and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buspirone and maprotiline both act on serotonergic and noradrenergic pathways, so serotonin toxicity is possible, although maprotiline is mainly a noradrenaline reuptake inhibitor. Maprotiline also lowers seizure threshold, which adds to the need for caution.
How serious is the interaction between Buspirone and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and increase gradually. Monitor for signs of serotonin syndrome, particularly after dose changes.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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