Drug interactions
Buspirone + Rifapentine
Severity: Moderate
Buspirone and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is an inducer of CYP3A4 and can lower buspirone concentrations substantially. The anxiolytic effect may be diminished during therapy and for some time after it ends.
What this interaction means in plain words
Buspirone and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4, increasing hepatic and intestinal metabolism of buspirone.
What to do
Monitor clinical response and increase the buspirone dose if needed. Reduce the dose again after rifapentine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Buspirone with Rifapentine?
MediHelp rates the interaction as moderate. Buspirone and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is an inducer of CYP3A4 and can lower buspirone concentrations substantially. The anxiolytic effect may be diminished during therapy and for some time after it ends.
How serious is the interaction between Buspirone and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the buspirone dose if needed. Reduce the dose again after rifapentine is stopped.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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