Drug interactions
Buspirone + Secobarbital
Severity: Moderate
Buspirone and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buspirone undergoes extensive CYP3A4 metabolism with high first-pass clearance. Barbiturate induction can lower buspirone levels and reduce anxiolytic benefit.
What this interaction means in plain words
Buspirone and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Secobarbital induces CYP3A4, increasing buspirone clearance.
What to do
Monitor anxiety control and adjust buspirone dose upward if effect is lost. Watch for toxicity if the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Secobarbital?
MediHelp rates the interaction as moderate. Buspirone and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buspirone undergoes extensive CYP3A4 metabolism with high first-pass clearance. Barbiturate induction can lower buspirone levels and reduce anxiolytic benefit.
How serious is the interaction between Buspirone and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor anxiety control and adjust buspirone dose upward if effect is lost. Watch for toxicity if the barbiturate is stopped.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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