Drug interactions
Butabarbital + Colchicine
Severity: Moderate
Butabarbital and Colchicine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and may increase P-glycoprotein activity, potentially lowering colchicine concentrations. This could reduce efficacy for gout flares or familial Mediterranean fever prophylaxis.
What this interaction means in plain words
Butabarbital and Colchicine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by butabarbital increases colchicine metabolism.
What to do
Monitor clinical response to colchicine and adjust the dose if control is lost. Reassess the dose if the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Butabarbital with Colchicine?
MediHelp rates the interaction as moderate. Butabarbital and Colchicine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and may increase P-glycoprotein activity, potentially lowering colchicine concentrations. This could reduce efficacy for gout flares or familial Mediterranean fever prophylaxis.
How serious is the interaction between Butabarbital and Colchicine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to colchicine and adjust the dose if control is lost. Reassess the dose if the barbiturate is stopped.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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