Drug interactions
Butabarbital + Dantrolene
Severity: Moderate
Butabarbital and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a barbiturate sedative and dantrolene causes drowsiness, so combined use can deepen sedation and impair alertness. Barbiturates may also add to respiratory depression.
What this interaction means in plain words
Butabarbital and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor sedation and respiratory status, and reduce the barbiturate dose if necessary. Avoid driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Butabarbital with Dantrolene?
MediHelp rates the interaction as moderate. Butabarbital and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is a barbiturate sedative and dantrolene causes drowsiness, so combined use can deepen sedation and impair alertness. Barbiturates may also add to respiratory depression.
How serious is the interaction between Butabarbital and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and reduce the barbiturate dose if necessary. Avoid driving until tolerance is established.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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