Drug interactions
Butabarbital + Duloxetine
Severity: Moderate
Butabarbital and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes, including CYP1A2, and may lower duloxetine concentrations, which could reduce antidepressant or analgesic effect. Additive sedation can also occur.
What this interaction means in plain words
Butabarbital and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction by butabarbital increases CYP1A2-mediated duloxetine metabolism, with additive CNS depression.
What to do
Monitor for loss of duloxetine efficacy and adjust dose if needed. Watch for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Butabarbital with Duloxetine?
MediHelp rates the interaction as moderate. Butabarbital and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes, including CYP1A2, and may lower duloxetine concentrations, which could reduce antidepressant or analgesic effect. Additive sedation can also occur.
How serious is the interaction between Butabarbital and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of duloxetine efficacy and adjust dose if needed. Watch for excess sedation.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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