Drug interactions
Butabarbital + Fluconazole
Severity: Minor
Butabarbital and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and may lower fluconazole exposure with prolonged use. This could reduce antifungal efficacy.
What this interaction means in plain words
Butabarbital and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Butabarbital induces hepatic CYP enzymes, which may increase fluconazole clearance.
What to do
Monitor clinical response to fluconazole in patients on chronic butabarbital and increase the dose if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Butabarbital with Fluconazole?
MediHelp rates the interaction as minor. Butabarbital and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates are enzyme inducers and may lower fluconazole exposure with prolonged use. This could reduce antifungal efficacy.
How serious is the interaction between Butabarbital and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to fluconazole in patients on chronic butabarbital and increase the dose if response is inadequate.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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