Drug interactions
Butabarbital + Mirtazapine
Severity: Moderate
Butabarbital and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and mirtazapine both depress the CNS, producing additive drowsiness and impaired coordination. Butabarbital may also induce CYP enzymes and lower mirtazapine concentrations over time.
What this interaction means in plain words
Butabarbital and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible hepatic enzyme induction by the barbiturate reducing mirtazapine exposure.
What to do
Monitor sedation and antidepressant response, and adjust the mirtazapine dose if efficacy falls. Advise avoiding alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Butabarbital with Mirtazapine?
MediHelp rates the interaction as moderate. Butabarbital and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and mirtazapine both depress the CNS, producing additive drowsiness and impaired coordination. Butabarbital may also induce CYP enzymes and lower mirtazapine concentrations over time.
How serious is the interaction between Butabarbital and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and antidepressant response, and adjust the mirtazapine dose if efficacy falls. Advise avoiding alcohol and driving.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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