Drug interactions
Butabarbital + Ondansetron
Severity: Minor
Butabarbital and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital induces hepatic CYP3A4 and other enzymes, which can speed ondansetron clearance and lower its levels. The antiemetic effect may be reduced, although ondansetron has multiple clearance pathways.
What this interaction means in plain words
Butabarbital and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases ondansetron metabolism.
What to do
No dose adjustment is routinely needed. If nausea control is inadequate, consider an additional antiemetic from a different class.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Butabarbital with Ondansetron?
MediHelp rates the interaction as minor. Butabarbital and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butabarbital induces hepatic CYP3A4 and other enzymes, which can speed ondansetron clearance and lower its levels. The antiemetic effect may be reduced, although ondansetron has multiple clearance pathways.
How serious is the interaction between Butabarbital and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed. If nausea control is inadequate, consider an additional antiemetic from a different class.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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