Drug interactions
Butabarbital + Pregabalin
Severity: Moderate
Butabarbital and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and pregabalin both depress the CNS, so combined use can cause marked drowsiness, impaired coordination and, at higher doses, respiratory depression.
What this interaction means in plain words
Butabarbital and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Use the lowest effective doses and monitor for oversedation and respiratory depression. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Frequently asked questions
Can I take Butabarbital with Pregabalin?
MediHelp rates the interaction as moderate. Butabarbital and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and pregabalin both depress the CNS, so combined use can cause marked drowsiness, impaired coordination and, at higher doses, respiratory depression.
How serious is the interaction between Butabarbital and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and respiratory depression. Advise against driving until the response is known.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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