Drug interactions
Butabarbital + Sotalol
Severity: Minor
Butabarbital and Sotalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital induces hepatic enzymes, but sotalol is eliminated mainly unchanged by the kidneys, so a meaningful drop in sotalol levels is unlikely. Any clinical effect is expected to be minimal.
What this interaction means in plain words
Butabarbital and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Enzyme induction has little effect because sotalol is not significantly metabolized.
What to do
No dose change is usually needed; monitor heart rate and blood pressure when the barbiturate is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Butabarbital with Sotalol?
MediHelp rates the interaction as minor. Butabarbital and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butabarbital induces hepatic enzymes, but sotalol is eliminated mainly unchanged by the kidneys, so a meaningful drop in sotalol levels is unlikely. Any clinical effect is expected to be minimal.
How serious is the interaction between Butabarbital and Sotalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor heart rate and blood pressure when the barbiturate is started or stopped.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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