Drug interactions
Butabarbital + Temsirolimus
Severity: Moderate
Butabarbital and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital, a barbiturate, induces CYP3A4 and may lower exposure to temsirolimus and sirolimus. This could reduce antitumor efficacy.
What this interaction means in plain words
Butabarbital and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4-mediated metabolism of temsirolimus.
What to do
Use a non-inducing alternative where possible. If unavoidable, monitor for loss of response; a higher temsirolimus dose may be considered per labeling for strong inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Butabarbital with Temsirolimus?
MediHelp rates the interaction as moderate. Butabarbital and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital, a barbiturate, induces CYP3A4 and may lower exposure to temsirolimus and sirolimus. This could reduce antitumor efficacy.
How serious is the interaction between Butabarbital and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing alternative where possible. If unavoidable, monitor for loss of response; a higher temsirolimus dose may be considered per labeling for strong inducers.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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