Drug interactions
Butabarbital + Trimipramine
Severity: Moderate
Butabarbital and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates add to the sedative effect of trimipramine and also induce liver enzymes, which may lower tricyclic concentrations. The result can be excess sedation along with reduced antidepressant effect.
What this interaction means in plain words
Butabarbital and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and CYP enzyme induction by barbiturates.
What to do
Monitor sedation and psychomotor function and watch for loss of antidepressant response. Adjust the trimipramine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Butabarbital with Trimipramine?
MediHelp rates the interaction as moderate. Butabarbital and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates add to the sedative effect of trimipramine and also induce liver enzymes, which may lower tricyclic concentrations. The result can be excess sedation along with reduced antidepressant effect.
How serious is the interaction between Butabarbital and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and psychomotor function and watch for loss of antidepressant response. Adjust the trimipramine dose if needed.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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