Drug interactions
Butalbital + Everolimus
Severity: Moderate
Butalbital and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that can induce CYP3A4 and may lower everolimus concentrations. The effect with intermittent low-dose use is likely smaller but may still reduce efficacy.
What this interaction means in plain words
Butalbital and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by barbiturates, increasing everolimus clearance.
What to do
Prefer a non-barbiturate analgesic, especially with regular use. If continued, monitor everolimus trough levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Butalbital with Everolimus?
MediHelp rates the interaction as moderate. Butalbital and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that can induce CYP3A4 and may lower everolimus concentrations. The effect with intermittent low-dose use is likely smaller but may still reduce efficacy.
How serious is the interaction between Butalbital and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-barbiturate analgesic, especially with regular use. If continued, monitor everolimus trough levels and clinical response.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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