Drug interactions
Butalbital + Fluconazole
Severity: Minor
Butalbital and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital, a barbiturate, may induce enzymes that lower fluconazole exposure with repeated use. Reduced antifungal effect is possible but unlikely with occasional use.
What this interaction means in plain words
Butalbital and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated hepatic enzyme induction may increase fluconazole clearance.
What to do
Monitor the response to fluconazole in patients using butalbital regularly and adjust the dose if infection control is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Butalbital with Fluconazole?
MediHelp rates the interaction as minor. Butalbital and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital, a barbiturate, may induce enzymes that lower fluconazole exposure with repeated use. Reduced antifungal effect is possible but unlikely with occasional use.
How serious is the interaction between Butalbital and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the response to fluconazole in patients using butalbital regularly and adjust the dose if infection control is poor.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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