Drug interactions
Butalbital + Loratadine
Severity: Minor
Butalbital and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital, a barbiturate, may induce metabolism of loratadine and lower its levels. The antihistamine effect may be reduced, with possible additive drowsiness.
What this interaction means in plain words
Butalbital and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 induction by butalbital increases loratadine metabolism.
What to do
Monitor for reduced allergy control and additive sedation; consider another antihistamine if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Frequently asked questions
Can I take Butalbital with Loratadine?
MediHelp rates the interaction as minor. Butalbital and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital, a barbiturate, may induce metabolism of loratadine and lower its levels. The antihistamine effect may be reduced, with possible additive drowsiness.
How serious is the interaction between Butalbital and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced allergy control and additive sedation; consider another antihistamine if efficacy is lost.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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