Drug interactions
Butalbital + Mirtazapine
Severity: Moderate
Butalbital and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that adds sedation and psychomotor impairment to mirtazapine. Enzyme induction by barbiturates may also lower mirtazapine levels with sustained use.
What this interaction means in plain words
Butalbital and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible enzyme induction by the barbiturate.
What to do
Use the lowest effective doses and monitor for oversedation. Review antidepressant response if butalbital is used frequently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Butalbital with Mirtazapine?
MediHelp rates the interaction as moderate. Butalbital and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that adds sedation and psychomotor impairment to mirtazapine. Enzyme induction by barbiturates may also lower mirtazapine levels with sustained use.
How serious is the interaction between Butalbital and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation. Review antidepressant response if butalbital is used frequently.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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