Drug interactions
Butalbital + Pregabalin
Severity: Moderate
Butalbital and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate and adds to the sedative effects of pregabalin, raising the risk of drowsiness, dizziness and impaired psychomotor function. Respiratory depression is possible at higher doses or in vulnerable patients.
What this interaction means in plain words
Butalbital and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Use the lowest effective doses and monitor for oversedation and respiratory depression. Counsel the patient to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Frequently asked questions
Can I take Butalbital with Pregabalin?
MediHelp rates the interaction as moderate. Butalbital and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate and adds to the sedative effects of pregabalin, raising the risk of drowsiness, dizziness and impaired psychomotor function. Respiratory depression is possible at higher doses or in vulnerable patients.
How serious is the interaction between Butalbital and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and respiratory depression. Counsel the patient to avoid driving and alcohol.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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