Drug interactions
Butalbital + Risperidone
Severity: Moderate
Butalbital and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that causes sedation, and risperidone can add to drowsiness and psychomotor impairment. Enzyme induction by barbiturates may also modestly reduce risperidone levels with prolonged use.
What this interaction means in plain words
Butalbital and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; barbiturate-mediated enzyme induction may lower risperidone exposure.
What to do
Monitor for excess sedation and counsel on avoiding driving or hazardous tasks. Reassess antipsychotic response if butalbital is used frequently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Butalbital with Risperidone?
MediHelp rates the interaction as moderate. Butalbital and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that causes sedation, and risperidone can add to drowsiness and psychomotor impairment. Enzyme induction by barbiturates may also modestly reduce risperidone levels with prolonged use.
How serious is the interaction between Butalbital and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and counsel on avoiding driving or hazardous tasks. Reassess antipsychotic response if butalbital is used frequently.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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