Drug interactions
Butalbital + Trimipramine
Severity: Moderate
Butalbital and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that adds to the sedation of trimipramine and may induce its metabolism. Excess drowsiness and impaired psychomotor performance are the main concerns.
What this interaction means in plain words
Butalbital and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and possible hepatic enzyme induction.
What to do
Advise patients about drowsiness and driving, and monitor antidepressant response when butalbital is used regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Butalbital with Trimipramine?
MediHelp rates the interaction as moderate. Butalbital and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that adds to the sedation of trimipramine and may induce its metabolism. Excess drowsiness and impaired psychomotor performance are the main concerns.
How serious is the interaction between Butalbital and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about drowsiness and driving, and monitor antidepressant response when butalbital is used regularly.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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