Drug interactions
Butalbital + Upadacitinib
Severity: Moderate
Butalbital and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that can induce CYP3A4 and may lower upadacitinib exposure, risking loss of efficacy. Strong CYP3A4 inducers are advised against in labeling.
What this interaction means in plain words
Butalbital and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 increases upadacitinib clearance.
What to do
Limit butalbital use to occasional doses and monitor disease control. Consider alternative headache therapy if use is regular.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Butalbital with Upadacitinib?
MediHelp rates the interaction as moderate. Butalbital and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that can induce CYP3A4 and may lower upadacitinib exposure, risking loss of efficacy. Strong CYP3A4 inducers are advised against in labeling.
How serious is the interaction between Butalbital and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit butalbital use to occasional doses and monitor disease control. Consider alternative headache therapy if use is regular.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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