Drug interactions
Butorphanol + Dantrolene
Severity: Moderate
Butorphanol and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness, dizziness and weakness, and these effects can be additive with an opioid. The combination can raise the risk of oversedation and, with muscle weakness, of respiratory compromise.
What this interaction means in plain words
Butorphanol and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; dantrolene also causes skeletal muscle weakness through inhibition of calcium release from the sarcoplasmic reticulum.
What to do
Monitor sedation and respiratory function, especially at initiation or dose increases. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Dantrolene
Frequently asked questions
Can I take Butorphanol with Dantrolene?
MediHelp rates the interaction as moderate. Butorphanol and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness, dizziness and weakness, and these effects can be additive with an opioid. The combination can raise the risk of oversedation and, with muscle weakness, of respiratory compromise.
How serious is the interaction between Butorphanol and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory function, especially at initiation or dose increases. Counsel patients to avoid driving and alcohol.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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