Drug interactions
Butorphanol + Melatonin
Severity: Minor
Butorphanol and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative properties that may add to opioid-induced drowsiness. The clinical effect is generally modest.
What this interaction means in plain words
Butorphanol and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Butorphanol belongs to Musculoskeletal; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive sedation from opioid activity and melatonin receptor-mediated hypnotic effect.
What to do
No dose change is usually needed; advise patients about additive drowsiness and monitor for excessive sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Butorphanol with Melatonin?
MediHelp rates the interaction as minor. Butorphanol and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative properties that may add to opioid-induced drowsiness. The clinical effect is generally modest.
How serious is the interaction between Butorphanol and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; advise patients about additive drowsiness and monitor for excessive sedation.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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