Drug interactions
Butorphanol + Methamphetamine
Severity: Moderate
Butorphanol and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stimulant effects of methamphetamine may partly offset opioid sedation, but they do not reverse respiratory depression and may mask impairment. Combined cardiovascular effects such as blood pressure changes can be unpredictable.
What this interaction means in plain words
Butorphanol and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Methamphetamine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic CNS effects; stimulant arousal may mask opioid sedation without removing respiratory depressant effects.
What to do
Monitor respiratory rate, blood pressure and heart rate, and do not rely on alertness as a sign of safe opioid dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Butorphanol with Methamphetamine?
MediHelp rates the interaction as moderate. Butorphanol and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stimulant effects of methamphetamine may partly offset opioid sedation, but they do not reverse respiratory depression and may mask impairment. Combined cardiovascular effects such as blood pressure changes can be unpredictable.
How serious is the interaction between Butorphanol and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate, blood pressure and heart rate, and do not rely on alertness as a sign of safe opioid dosing.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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