Drug interactions
Butorphanol + Midodrine
Severity: Minor
Butorphanol and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine does not meaningfully counter opioid sedation and has no clear pharmacological interaction with butorphanol. Interaction is poorly characterized, with no established clinically important effect.
What this interaction means in plain words
Butorphanol and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Butorphanol belongs to Musculoskeletal; Midodrine belongs to Miscellaneous.
Why it happens
No established mechanism; effects on sedation are not documented.
What to do
No specific action is required; monitor blood pressure and sedation as usual with each drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Butorphanol with Midodrine?
MediHelp rates the interaction as minor. Butorphanol and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midodrine does not meaningfully counter opioid sedation and has no clear pharmacological interaction with butorphanol. Interaction is poorly characterized, with no established clinically important effect.
How serious is the interaction between Butorphanol and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; monitor blood pressure and sedation as usual with each drug.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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