Drug interactions
Butorphanol + Modafinil
Severity: Minor
Butorphanol and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil promotes wakefulness and may partly counter opioid drowsiness, but it does not reduce opioid respiratory depression. Alertness may therefore mask impairment.
What this interaction means in plain words
Butorphanol and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Butorphanol belongs to Musculoskeletal; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on arousal; no established pharmacokinetic interaction of significance.
What to do
No dose adjustment is generally needed; monitor respiratory status and efficacy of analgesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Modafinil
Frequently asked questions
Can I take Butorphanol with Modafinil?
MediHelp rates the interaction as minor. Butorphanol and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil promotes wakefulness and may partly counter opioid drowsiness, but it does not reduce opioid respiratory depression. Alertness may therefore mask impairment.
How serious is the interaction between Butorphanol and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor respiratory status and efficacy of analgesia.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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