Drug interactions
Butorphanol + Sevoflurane
Severity: Moderate
Butorphanol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butorphanol and sevoflurane both depress the central nervous system. Together they deepen sedation and anesthesia and can increase respiratory and cardiovascular depression. Butorphanol is commonly used as an anesthetic adjunct, so the effect is expected and requires dose awareness.
What this interaction means in plain words
Butorphanol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression from opioid agonist activity plus volatile anesthetic effects.
What to do
Titrate sevoflurane concentration and butorphanol dose to effect, and monitor respiratory rate, oxygenation and blood pressure. Reduce the anesthetic requirement as needed and ensure ventilatory support is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Butorphanol with Sevoflurane?
MediHelp rates the interaction as moderate. Butorphanol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butorphanol and sevoflurane both depress the central nervous system. Together they deepen sedation and anesthesia and can increase respiratory and cardiovascular depression. Butorphanol is commonly used as an anesthetic adjunct, so the effect is expected and requires dose awareness.
How serious is the interaction between Butorphanol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane concentration and butorphanol dose to effect, and monitor respiratory rate, oxygenation and blood pressure. Reduce the anesthetic requirement as needed and ensure ventilatory support is available.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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