Drug interactions
Butorphanol + Stiripentol
Severity: Moderate
Butorphanol and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol is an antiepileptic that frequently causes somnolence and inhibits several CYP enzymes. With butorphanol, additive sedation and respiratory depression may occur.
What this interaction means in plain words
Butorphanol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible increased butorphanol exposure through CYP3A4 inhibition.
What to do
Monitor sedation and respiratory status, and start butorphanol at lower doses. Adjust doses based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Butorphanol with Stiripentol?
MediHelp rates the interaction as moderate. Butorphanol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol is an antiepileptic that frequently causes somnolence and inhibits several CYP enzymes. With butorphanol, additive sedation and respiratory depression may occur.
How serious is the interaction between Butorphanol and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and start butorphanol at lower doses. Adjust doses based on response.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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