Drug interactions
Apalutamide + Stiripentol
Severity: Major
Apalutamide and Stiripentol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower stiripentol concentrations, possibly reducing seizure control in Dravet syndrome. Stiripentol is cleared by several CYP enzymes, so induction has an additive effect.
What this interaction means in plain words
Apalutamide and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Apalutamide induces CYP3A4 and CYP2C19 (and other CYPs), increasing stiripentol clearance.
What to do
Avoid if possible. If coadministered, monitor seizure frequency closely and consider increasing the stiripentol dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Apalutamide with Stiripentol?
MediHelp rates the interaction as major. Apalutamide and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may lower stiripentol concentrations, possibly reducing seizure control in Dravet syndrome. Stiripentol is cleared by several CYP enzymes, so induction has an additive effect.
How serious is the interaction between Apalutamide and Stiripentol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If coadministered, monitor seizure frequency closely and consider increasing the stiripentol dose.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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