Drug interactions
Flibanserin + Stiripentol
Severity: Major
Flibanserin and Stiripentol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19 and has mixed CYP3A4 effects, so flibanserin exposure may rise and cause hypotension, syncope and sedation. Net effects are unpredictable.
What this interaction means in plain words
Flibanserin and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flibanserin belongs to Genitourinary; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 and variable modulation of CYP3A4 metabolism of flibanserin by stiripentol.
What to do
Avoid if possible; otherwise monitor for sedation, dizziness and low blood pressure and consider a lower flibanserin dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Flibanserin with Stiripentol?
MediHelp rates the interaction as major. Flibanserin and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Stiripentol inhibits CYP2C19 and has mixed CYP3A4 effects, so flibanserin exposure may rise and cause hypotension, syncope and sedation. Net effects are unpredictable.
How serious is the interaction between Flibanserin and Stiripentol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor for sedation, dizziness and low blood pressure and consider a lower flibanserin dose.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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