Drug interactions
Ergotamine + Stiripentol
Severity: Major
Ergotamine and Stiripentol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP3A4 and other enzymes, which may raise ergotamine concentrations. This increases the risk of ergotism with vasospasm and ischemia.
What this interaction means in plain words
Ergotamine and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP3A4, reducing ergotamine metabolism; its inducing effects are mixed.
What to do
Avoid the combination if possible and use an alternative migraine therapy. If it cannot be avoided, monitor for ischemic symptoms and use the lowest ergotamine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Ergotamine with Stiripentol?
MediHelp rates the interaction as major. Ergotamine and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Stiripentol inhibits CYP3A4 and other enzymes, which may raise ergotamine concentrations. This increases the risk of ergotism with vasospasm and ischemia.
How serious is the interaction between Ergotamine and Stiripentol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use an alternative migraine therapy. If it cannot be avoided, monitor for ischemic symptoms and use the lowest ergotamine dose.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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