Drug interactions
Lorlatinib + Stiripentol
Severity: Major
Lorlatinib and Stiripentol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes including CYP3A4 and may increase lorlatinib exposure and adverse effects. Lorlatinib may also lower stiripentol levels through CYP3A induction, risking loss of seizure control.
What this interaction means in plain words
Lorlatinib and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorlatinib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP3A4, reducing lorlatinib clearance; lorlatinib induces CYP3A4, increasing stiripentol metabolism.
What to do
Avoid if possible. If unavoidable, monitor lipids, liver enzymes, CNS effects and ECG, consider reducing lorlatinib dose, and watch for loss of seizure control.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Lorlatinib with Stiripentol?
MediHelp rates the interaction as major. Lorlatinib and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Stiripentol inhibits several CYP enzymes including CYP3A4 and may increase lorlatinib exposure and adverse effects. Lorlatinib may also lower stiripentol levels through CYP3A induction, risking loss of seizure control.
How serious is the interaction between Lorlatinib and Stiripentol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, monitor lipids, liver enzymes, CNS effects and ECG, consider reducing lorlatinib dose, and watch for loss of seizure control.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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